MTDH mediates trastuzumab resistance in HER2 positive breast cancer by decreasing PTEN expression through an NFκB-dependent pathway

BACKGROUND: Trastuzumab resistance is almost inevitable in the management of human epidermal growth factor receptor (HER) 2 positive breast cancer, in which phosphatase and tensin homolog deleted from chromosome 10 (PTEN) loss is implicated. Since metadherin (MTDH) promotes malignant phenotype of br...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Du, Cheng, Yi, Xiaomin, Liu, Wenchao, Han, Tao, Liu, Zhaozhe, Ding, Zhenyu, Zheng, Zhendong, Piao, Ying, Yuan, Jianlin, Han, Yaling, Xie, Manjiang, Xie, Xiaodong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254009/
https://ncbi.nlm.nih.gov/pubmed/25417825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-869
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