Characterization of the Anopheles gambiae octopamine receptor and discovery of potential agonists and antagonists using a combined computational-experimental approach

BACKGROUND: Octopamine receptors (OARs) perform key functions in the biological pathways of primarily invertebrates, making this class of G-protein coupled receptors (GPCRs) a potentially good target for insecticides. However, the lack of structural and experimental data for this insect-essential GP...

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Detalhes bibliográficos
Publicado no:Malar J
Main Authors: Kastner, Kevin W, Shoue, Douglas A, Estiu, Guillermina L, Wolford, Julia, Fuerst, Megan F, Markley, Lowell D, Izaguirre, Jesús A, McDowell, Mary Ann
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253978/
https://ncbi.nlm.nih.gov/pubmed/25407998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-13-434
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