Copper-uptake is critical for the down regulation of synapsin and dynamin induced by neocuproine: modulation of synaptic activity in hippocampal neurons

Extracellular and intracellular copper and zinc regulate synaptic activity and plasticity, which may impact brain functionality and human behavior. We have found that a metal coordinating molecule, Neocuproine, transiently increases free intracellular copper and zinc levels (i.e., min) in hippocampa...

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Detalhes bibliográficos
Publicado no:Front Aging Neurosci
Main Authors: Castro, Patricio A., Ramirez, Alejandra, Sepúlveda, Fernando J., Peters, Christian, Fierro, Humberto, Waldron, Javier, Luza, Sandra, Fuentealba, Jorge, Muñoz, Francisco J., De Ferrari, Giancarlo V., Bush, Ashley I., Aguayo, Luis G., Opazo, Carlos M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253966/
https://ncbi.nlm.nih.gov/pubmed/25520655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2014.00319
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