Identifying bias in CCR1 antagonists using radiolabelled binding, receptor internalization, β-arrestin translocation and chemotaxis assays

BACKGROUND AND PURPOSE: Investigators have suggested that the chemokine receptor CCR1 plays a role in multiple myeloma. Studies using antisense and neutralizing antibodies to CCR1 showed that down-regulation of the receptor altered disease progression in a mouse model. More recently, experiments uti...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Gilchrist, A, Gauntner, T D, Fazzini, A, Alley, K M, Pyen, D S, Ahn, J, Ha, S J, Willett, A, Sansom, S E, Yarfi, J L, Bachovchin, K A, Mazzoni, M R, Merritt, J R
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253460/
https://ncbi.nlm.nih.gov/pubmed/24990525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12835
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