Control of polyclonal immunoglobulin production from human lymphocytes by leukotrienes; leukotriene B4 induces an OKT8(+), radiosensitive suppressor cell from resting, human OKT8(-) T cells.

We report that leukotriene B4 (LTB4), a 5-lipoxygenase metabolite of arachidonic acid, is a potent suppressor of polyclonal Ig production in pokeweed mitogen (PWM)-stimulated cultures of human peripheral blood lymphocytes, while LTC4 and LTD4 have little activity in this system. Preincubation of T c...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Atluru, D, Goodwin, J S
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1984
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC425313/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6090503/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI111556
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