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NGF blockade at early times during bone cancer development attenuates bone destruction and increases limb use

Studies in animals and humans show that blockade of nerve growth factor (NGF) attenuates both malignant and non-malignant skeletal pain. While reduction of pain is important, a largely unanswered question is what other benefits NGF blockade might confer in bone cancer patients. Using a mouse graft m...

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Publicat a:Cancer Res
Autors principals: McCaffrey, Gwen, Thompson, Michelle L., Majuta, Lisa, Fealk, Michelle N., Chartier, Stephane, Longo, Geraldine, Mantyh, Patrick W.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253026/
https://ncbi.nlm.nih.gov/pubmed/25287160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1220
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