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Inhibition of human Cytochrome P450 2E1 and 2A6 by aldehydes: Structure and activity relationships
The purpose of this study was to probe active site structure and dynamics of human cytochrome P450(2E1) and P450(2A6) using a series of related short chain fatty aldehydes. Binding efficiency of the aldehydes was monitored via their ability to inhibit the binding and activation of the probe substrat...
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| Veröffentlicht in: | Chem Biol Interact |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4252262/ https://ncbi.nlm.nih.gov/pubmed/24924949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2014.05.014 |
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