Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor

Oxidative stress suppresses host immunity by generating oxidized lipid agonists of the platelet-activating factor receptor (PAF-R). Because many classical chemotherapeutic drugs induce reactive oxygen species (ROS), we investigated whether these drugs might subvert host immunity by activating PAF-R....

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Udgivet i:Cancer Res
Main Authors: Sahu, Ravi P., Ocana, Jesus A., Harrison, Kathleen A., Ferracini, Matheus, Touloukian, Christopher E., Al-Hassani, Mohammed, Sun, Louis, Loesch, Mathew, Murphy, Robert C., Althouse, Sandra K., Perkins, Susan M., Speicher, Paul J., Tyler, Douglas S., Konger, Raymond L., Travers, Jeffrey B.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252249/
https://ncbi.nlm.nih.gov/pubmed/25304264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2043
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