Tacrolimus (FK506) Suppresses TREM-1 Expression at an Early but Not at a Late Stage in a Murine Model of Fungal Keratitis

PURPOSE: To investigate the efficacy and mechanism of tacrolimus(FK506), which is a novel macrolide immunosuppressant, in inhibiting triggering receptor expressed on myeloid cells-1 (TREM-1) expression in a murine keratitis model induced by Aspergillus fumigatus. METHOD: TREM-1 was detected in 11 fu...

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Pubblicato in:PLoS One
Autori principali: Huang, Weilan, Ling, Shiqi, Jia, Xiuhua, Lin, Binwu, Huang, Xi, Zhong, Jing, Li, Weihua, Lin, Xiaolei, Sun, Yifang, Yuan, Jin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252117/
https://ncbi.nlm.nih.gov/pubmed/25464008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114386
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