Simultaneous alteration of residues 279 and 284 of the VP2 major capsid protein of a very virulent Infectious Bursal Disease Virus (vvIBDV) strain did not lead to attenuation in chickens

BACKGROUND: Cell culture adaptation of very virulent infectious bursal disease virus (vvIBDV) was shown to be mainly associated with the VP2 capsid protein residues 253, 279, and 284. The single mutation A284T proved critical for cell culture tropism, but did not confer efficient virus replication,...

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Detalhes bibliográficos
Publicado no:Virol J
Main Authors: Abdeljelil, Nawel Ben, Khabouchi, Neila, Kassar, Selma, Miled, Khaled, Boubaker, Samir, Ghram, Abdeljelil, Mardassi, Helmi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252001/
https://ncbi.nlm.nih.gov/pubmed/25420540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12985-014-0199-7
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