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Profiling of Cxcl12 Receptors, Cxcr4 and Cxcr7 in Murine Testis Development and a Spermatogenic Depletion Model Indicates a Role for Cxcr7 in Controlling Cxcl12 Activity

In mice the chemokine Cxcl12 and its receptor Cxcr4 participate in maintenance of the spermatogonial population during postnatal development. More complexity arises since Cxcl12 also binds to the non-classical/atypical chemokine receptor Cxcr7. We explored the expression pattern of Cxcl12, Cxcr4 and...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Westernströer, Birgit, Terwort, Nicole, Ehmcke, Jens, Wistuba, Joachim, Schlatt, Stefan, Neuhaus, Nina
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4251904/
https://ncbi.nlm.nih.gov/pubmed/25460567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112598
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