High-temperature cultivation of recombinant Pichia pastoris increases endoplasmic reticulum stress and decreases production of human interleukin-10

BACKGROUND: The yeast Pichia pastoris (P. pastoris) has become a popular ‘cell factory’ for producing heterologous proteins, but production widely varies among proteins. Cultivation temperature is frequently reported to significantly affect protein production; however, the underlying mechanisms of t...

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Bibliographic Details
Published in:Microb Cell Fact
Main Authors: Zhong, Yongjun, Yang, Lu, Guo, Yugang, Fang, Fang, Wang, Dong, Li, Rui, Jiang, Ming, Kang, Wenyao, Ma, Jiajia, Sun, Jie, Xiao, Weihua
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4251845/
https://ncbi.nlm.nih.gov/pubmed/25425395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-014-0163-7
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