Hepatic Insulin Resistance is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis

Insulin resistance plays a central role in the development of the metabolic syndrome, but how it relates to cardiovascular disease remains controversial. Liver insulin receptor knockout (LIRKO) mice have pure hepatic insulin resistance. On a chow diet, LIRKO mice have a proatherogenic lipoprotein pr...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Biddinger, Sudha B., Hernandez-Ono, Antonio, Rask-Madsen, Christian, Haas, Joel T., Alemán, José O., Suzuki, Ryo, Scapa, Erez F., Agarwal, Chhavi, Carey, Martin C., Stephanopoulos, Gregory, Cohen, David E., King, George L., Ginsberg, Henry, Kahn, C. Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4251554/
https://ncbi.nlm.nih.gov/pubmed/18249172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2007.11.013
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