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Differentiation of pluripotent stem cells into striatal projection neurons: a pure MSN fate may not be sufficient
Huntington’s disease (HD) is an autosomal dominant inherited disorder leading to the loss inter alia of DARPP-32 positive medium spiny projection neurons (“MSNs”) in the striatum. There is no known cure for HD but the relative specificity of cell loss early in the disease has made cell replacement b...
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| Publicado no: | Front Cell Neurosci |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4251433/ https://ncbi.nlm.nih.gov/pubmed/25520619 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00398 |
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