Qualitative and quantitative differences in the pathways of extrathyroidal triiodothyronine generation between euthyroid and hypothyroid rats.

Propylthiouracil (PTU) in maximally inhibitory doses for liver and kidney iodothyronine 5'-deiodinase activity (5'D-I), reduces extrathyroidal T4 to T3 conversion by only 60-70% in euthyroid rats. A second pathway of T4 to T3 conversion (5'D-II) has been found in pituitary, central nervous system, a...

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Pubblicato in:	J Clin Invest
Autori principali:	Silva, J E, Gordon, M B, Crantz, F R, Leonard, J L, Larsen, P R
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1984
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC425100/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6707210/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI111313
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