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The Directional Response of Chemotactic Cells Depends on a Balance between Cytoskeletal Architecture and the External Gradient
Polarized migrating cells display signal transduction events, such as activation of PI3K and Scar/Wave, and respond more readily to chemotactic stimuli at the leading edge. We sought to determine the basis of this polarized sensitivity. Inhibiting actin polymerization leads to uniform sensitivity. H...
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| Publicado no: | Cell Rep |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4250826/ https://ncbi.nlm.nih.gov/pubmed/25437564 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.09.047 |
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