Stable expression of HIF-1α in tubular epithelial cells promotes interstitial fibrosis

Chronic hypoxia accelerates renal fibrosis. The chief mediator of the hypoxic response is hypoxia-inducible factor 1 (HIF-1) and its oxygen-sensitive component HIF-1α. HIF-1 regulates a wide variety of genes, some of which are closely associated with tissue fibrosis. To determine the specific role o...

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Detalhes bibliográficos
Publicado no:Am J Physiol Renal Physiol
Main Authors: Kimura, Kuniko, Iwano, Masayuki, Higgins, Debra F., Yamaguchi, Yukinari, Nakatani, Kimihiko, Harada, Koji, Kubo, Atsushi, Akai, Yasuhiro, Rankin, Erinn B., Neilson, Eric G., Haase, Volker H., Saito, Yoshihiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250235/
https://ncbi.nlm.nih.gov/pubmed/18667485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.90209.2008
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