Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain

We have purified and reconstituted human transient receptor potential (TRP) subtype A1 (hTRPA1) into lipid bilayers and recorded single-channel currents to understand its inherent thermo- and chemosensory properties as well as the role of the ankyrin repeat domain (ARD) of the N terminus in channel...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Moparthi, Lavanya, Survery, Sabeen, Kreir, Mohamed, Simonsen, Charlotte, Kjellbom, Per, Högestätt, Edward D., Johanson, Urban, Zygmunt, Peter M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250169/
https://ncbi.nlm.nih.gov/pubmed/25389312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412689111
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