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Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain
We have purified and reconstituted human transient receptor potential (TRP) subtype A1 (hTRPA1) into lipid bilayers and recorded single-channel currents to understand its inherent thermo- and chemosensory properties as well as the role of the ankyrin repeat domain (ARD) of the N terminus in channel...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4250169/ https://ncbi.nlm.nih.gov/pubmed/25389312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412689111 |
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