Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity.

Affinity maturation of IgG antibodies in adaptive immune responses is a well-accepted mechanism to improve effector functions of IgG within 2 weeks to several months of antigen encounter. This concept has been defined mainly for IgG responses against chemically defined haptens. We have evaluated thi...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Roost, H P, Bachmann, M F, Haag, A, Kalinke, U, Pliska, V, Hengartner, H, Zinkernagel, R M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42498/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7877965/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.5.1257
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