KPC-Producing Klebsiella pneumoniae Strains That Harbor AAC(6′)-Ib Exhibit Intermediate Resistance to Amikacin

The aminoglycoside-modifying enzyme AAC(6′)-Ib is common among carbapenem-resistant Klebsiella pneumoniae (CR-Kp) strains. We investigated amikacin (AMK) activity against 20 AAC(6′)-Ib-producing CR-Kp strains. MICs clustered at 16 to 32 μg/ml. By the time-kill study, AMK (1× and 4× the MIC) was bact...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Bremmer, Derek N., Clancy, Cornelius J., Press, Ellen G., Almaghrabi, Reem, Chen, Liang, Doi, Yohei, Nguyen, M. Hong, Shields, Ryan K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249530/
https://ncbi.nlm.nih.gov/pubmed/25288089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03831-14
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