A Drug-Repositioning Screening Identifies Pentetic Acid as a Potential Therapeutic Agent for Suppressing the Elastase-Mediated Virulence of Pseudomonas aeruginosa

Pseudomonas aeruginosa, a Gram-negative bacterium of clinical significance, produces elastase as a predominant exoprotease. Here, we screened a library of chemical compounds currently used for human medication and identified diethylene triamine penta-acetic acid (DTPA, pentetic acid) as an agent tha...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Gi, Mia, Jeong, Junhui, Lee, Keehoon, Lee, Kang-Mu, Toyofuku, Masanori, Yong, Dong Eun, Yoon, Sang Sun, Choi, Jae Young
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Clinical Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249511/
https://ncbi.nlm.nih.gov/pubmed/25246397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03063-14
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