NOD2 Stimulation by Staphylococcus aureus-Derived Peptidoglycan Is Boosted by Toll-Like Receptor 2 Costimulation with Lipoproteins in Dendritic Cells

Mutations in the nucleotide-binding oligomerization domain-containing protein 2 (NOD2) play an important role in the pathogenesis of Crohn's disease. NOD2 is an intracellular pattern recognition receptor (PRR) that senses bacterial peptidoglycan (PGN) structures, e.g., muramyl dipeptide (MDP)....

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Schäffler, Holger, Demircioglu, Dogan Doruk, Kühner, Daniel, Menz, Sarah, Bender, Annika, Autenrieth, Ingo B., Bodammer, Peggy, Lamprecht, Georg, Götz, Friedrich, Frick, Julia-Stefanie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249339/
https://ncbi.nlm.nih.gov/pubmed/25156723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02043-14
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