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Characterization of a Lipopolysaccharide-Targeted Monoclonal Antibody and Its Variable Fragments as Candidates for Prophylaxis against the Obligate Intracellular Bacterial Pathogen Coxiella burnetii

Our previous study demonstrated that treatment of Coxiella burnetii with the phase I lipopolysaccharide (PI-LPS)-targeted monoclonal antibody (MAb) 1E4 significantly inhibited C. burnetii infection in mice, suggesting that 1E4 is a protective MAb. To determine whether passive transfer of antibodies...

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Détails bibliographiques
Publié dans:Infect Immun
Auteurs principaux: Peng, Ying, Schoenlaub, Laura, Elliott, Alexandra, Mitchell, William J., Zhang, Guoquan
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249325/
https://ncbi.nlm.nih.gov/pubmed/25114119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01695-14
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