Recombinant Hepatitis C Virus Envelope Glycoprotein Vaccine Elicits Antibodies Targeting Multiple Epitopes on the Envelope Glycoproteins Associated with Broad Cross-Neutralization

Although effective hepatitis C virus (HCV) antivirals are on the horizon, a global prophylactic vaccine for HCV remains elusive. The diversity of the virus is a major concern for vaccine development; there are 7 major genotypes of HCV found globally. Therefore, a successful vaccine will need to prot...

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Bibliographic Details
Published in:J Virol
Main Authors: Wong, Jason Alexander Ji-Xhin, Bhat, Rakesh, Hockman, Darren, Logan, Michael, Chen, Chao, Levin, Aviad, Frey, Sharon E., Belshe, Robert B., Tyrrell, D. Lorne, Law, John Lok Man, Houghton, Michael
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249152/
https://ncbi.nlm.nih.gov/pubmed/25275133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01911-14
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