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Blocking ESCRT-Mediated Envelopment Inhibits Microtubule-Dependent Trafficking of Alphaherpesviruses In Vitro

Herpes simplex virus (HSV) and, as reported here, pseudorabies virus (PRV) utilize the ESCRT apparatus to drive cytoplasmic envelopment of their capsids. Here, we demonstrate that blocking ESCRT-mediated envelopment using the dominant-negative inhibitor Vps4A-EQ (Vps4A in which glutamate [E] at posi...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Kharkwal, Himanshu, Smith, Caitlin G., Wilson, Duncan W.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249151/
https://ncbi.nlm.nih.gov/pubmed/25297998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02777-14
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