Lack of Interleukin-10-Mediated Anti-Inflammatory Signals and Upregulated Interferon Gamma Production Are Linked to Increased Intestinal Epithelial Cell Apoptosis in Pathogenic Simian Immunodeficiency Virus Infection

Interleukin-10 (IL-10) is an immunomodulatory cytokine that is important for maintenance of epithelial cell (EC) survival and anti-inflammatory responses (AIR). The majority of HIV infections occur through the mucosal route despite mucosal epithelium acting as a barrier to human immunodeficiency vir...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Pan, Diganta, Kenway-Lynch, Carys S., Lala, Wendy, Veazey, Ronald S., Lackner, Andrew A., Das, Arpita, Pahar, Bapi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249077/
https://ncbi.nlm.nih.gov/pubmed/25165117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01757-14
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