Distinct Mechanisms Regulate Exposure of Neutralizing Epitopes in the V2 and V3 Loops of HIV-1 Envelope

Broadly neutralizing antibodies targeting the HIV-1 envelope (Env) are key components for protection against HIV-1. However, many cross-reactive epitopes are often occluded. This study investigates the mechanisms contributing to the masking of V2i (variable loop V2 integrin) epitopes compared to the...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Upadhyay, Chitra, Mayr, Luzia M., Zhang, Jing, Kumar, Rajnish, Gorny, Miroslaw K., Nádas, Arthur, Zolla-Pazner, Susan, Hioe, Catarina E.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2014
Sujets:
Vaccines and Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248937/
https://ncbi.nlm.nih.gov/pubmed/25165106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02125-14
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