Human Papillomavirus Type 1 E1^E4 Protein Is a Potent Inhibitor of the Serine-Arginine (SR) Protein Kinase SRPK1 and Inhibits Phosphorylation of Host SR Proteins and of the Viral Transcription and Replication Regulator E2

The serine-arginine-specific protein kinase SRPK1 is a common binding partner of the E1^E4 protein of diverse human papillomavirus types. We show here for the first time that the interaction between HPV1 E1^E4 and SRPK1 leads to potent inhibition of SRPK1 phosphorylation of host serine-arginine (SR)...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Prescott, Emma L., Brimacombe, Claire L., Hartley, Margaret, Bell, Ian, Graham, Sheila, Roberts, Sally
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248925/
https://ncbi.nlm.nih.gov/pubmed/25142587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02029-14
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