Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1.

Aflatoxin B1 (AFB1) has been postulated to be a hepatocarcinogen in humans, possibly by causing p53 mutations at codon 249. AFB1 is metabolized via the phase I and II detoxification pathways; hence, genetic variation at those loci may predict susceptibility to the effects of AFB1. To test this hypot...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	McGlynn, K A, Rosvold, E A, Lustbader, E D, Hu, Y, Clapper, M L, Zhou, T, Wild, C P, Xia, X L, Baffoe-Bonnie, A, Ofori-Adjei, D
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42488/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7892276/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.6.2384
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!