Does IGFR1 inhibition result in increased muscle mass loss in patients undergoing treatment for pancreatic cancer?

BACKGROUND: IGF-1 plays a role in the growth of multiple tumor types, including pancreatic cancer. IGF-1 also serves as a growth factor for muscle. The impact of therapeutic targeting of IGF-1 on muscle mass is unknown. METHODS: We evaluated muscle mass at L3 in patients enrolled in a randomized pha...

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Pubblicato in:J Cachexia Sarcopenia Muscle
Autori principali: Fogelman, David R., Holmes, Holly, Mohammed, Khalil, Katz, Matthew H. G., Prado, Carla M., Lieffers, Jessica, Garg, Naveen, Varadhachary, Gauri R., Shroff, Rachna, Overman, Michael J., Garrett, Christopher, Wolff, Robert A., Javle, Milind
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2014
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248412/
https://ncbi.nlm.nih.gov/pubmed/24740741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13539-014-0145-y
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