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Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor.

Autoimmunity often involves the abnormal targeting of self-antigens by antibodies, leading to tissue destruction and other pathologies. This process could potentially be disrupted by small ligands that bind specifically to autoantibodies and inhibit their interaction with the target antigen. Here we...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Doudna, J A, Cech, T R, Sullenger, B A
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1995
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42482/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7534420/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.6.2355
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