MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus

Activation of melanocortin-4 receptors (MC4Rs) restrains feeding and prevents obesity; however, the identity, location, and axonal projections of the neurons bearing MC4Rs that control feeding remain unknown. Reexpression of MC4Rs on single-minded 1 (SIM1)(+) neurons in mice otherwise lacking MC4Rs...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Shah, Bhavik P., Vong, Linh, Olson, David P., Koda, Shuichi, Krashes, Michael J., Ye, Chianping, Yang, Zongfang, Fuller, Patrick M., Elmquist, Joel K., Lowell, Bradford B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246954/
https://ncbi.nlm.nih.gov/pubmed/25157144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407843111
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