The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation

The two-pore channels (TPC1 and TPC2) belong to an ancient family of intracellular ion channels expressed in the endolysosomal system. Little is known about how regulatory inputs converge to modulate TPC activity, and proposed activation mechanisms are controversial. Here, we compiled a proteomic ch...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Lin-Moshier, Yaping, Keebler, Michael V., Hooper, Robert, Boulware, Michael J., Liu, Xiaolong, Churamani, Dev, Abood, Mary E., Walseth, Timothy F., Brailoiu, Eugen, Patel, Sandip, Marchant, Jonathan S.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2014
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246952/
https://ncbi.nlm.nih.gov/pubmed/25157141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407004111
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