The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation

The two-pore channels (TPC1 and TPC2) belong to an ancient family of intracellular ion channels expressed in the endolysosomal system. Little is known about how regulatory inputs converge to modulate TPC activity, and proposed activation mechanisms are controversial. Here, we compiled a proteomic ch...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Lin-Moshier, Yaping, Keebler, Michael V., Hooper, Robert, Boulware, Michael J., Liu, Xiaolong, Churamani, Dev, Abood, Mary E., Walseth, Timothy F., Brailoiu, Eugen, Patel, Sandip, Marchant, Jonathan S.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246952/
https://ncbi.nlm.nih.gov/pubmed/25157141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407004111
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