Single-cell mass cytometry of TCR signaling: Amplification of small initial differences results in low ERK activation in NOD mice

Signaling from the T-cell receptor (TCR) conditions T-cell differentiation and activation, requiring exquisite sensitivity and discrimination. Using mass cytometry, a high-dimensional technique that can probe multiple signaling nodes at the single-cell level, we interrogate TCR signaling dynamics in...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Mingueneau, Michael, Krishnaswamy, Smita, Spitzer, Matthew H., Bendall, Sean C., Stone, Erica L., Hedrick, Stephen M., Pe'er, Dana, Mathis, Diane, Nolan, Garry P., Benoist, Christophe
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246343/
https://ncbi.nlm.nih.gov/pubmed/25362052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419337111
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