Non-antibiotic quorum sensing inhibitors acting against N-acyl homoserine lactone synthase as druggable target

N-acylhomoserine lactone (AHL)-based quorum sensing (QS) is important for the regulation of proteobacterial virulence determinants. Thus, the inhibition of AHL synthases offers non-antibiotics-based therapeutic potentials against QS-mediated bacterial infections. In this work, functional AHL synthas...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Chang, Chien-Yi, Krishnan, Thiba, Wang, Hao, Chen, Ye, Yin, Wai-Fong, Chong, Yee-Meng, Tan, Li Ying, Chong, Teik Min, Chan, Kok-Gan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246208/
https://ncbi.nlm.nih.gov/pubmed/25430794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07245
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