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Blockade of Gap Junction Hemichannel Protects Secondary Spinal Cord Injury from Activated Microglia-Mediated Glutamate Exitoneurotoxicity
We previously demonstrated that activated microglia release excessive glutamate through gap junction hemichannels and identified a novel gap junction hemichannel blocker, INI-0602, that was proven to penetrate the blood–brain barrier and be an effective treatment in mouse models of amyotrophic later...
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Publicado no: | J Neurotrauma |
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Main Authors: | , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Mary Ann Liebert, Inc.
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4245850/ https://ncbi.nlm.nih.gov/pubmed/24588281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/neu.2013.3223 |
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