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Blockade of Gap Junction Hemichannel Protects Secondary Spinal Cord Injury from Activated Microglia-Mediated Glutamate Exitoneurotoxicity

We previously demonstrated that activated microglia release excessive glutamate through gap junction hemichannels and identified a novel gap junction hemichannel blocker, INI-0602, that was proven to penetrate the blood–brain barrier and be an effective treatment in mouse models of amyotrophic later...

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Detalhes bibliográficos
Publicado no:J Neurotrauma
Main Authors: Umebayashi, Daisuke, Natsume, Atsushi, Takeuchi, Hideyuki, Hara, Masahito, Nishimura, Yusuke, Fukuyama, Ryuichi, Sumiyoshi, Naoyuki, Wakabayashi, Toshihiko
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245850/
https://ncbi.nlm.nih.gov/pubmed/24588281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/neu.2013.3223
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