12-o-Tetradecanoyl-phorbol-13-acetate-differentiated U937 cells express a macrophage-like profile of neutral proteinases. High levels of secreted collagenase and collagenase inhibitor accompany low levels of intracellular elastase and cathepsin G.

Human monocytic tumor cells of the U937 cell line contain substantial quantities of two neutrophil neutral proteinases, elastase and cathepsin G, raising the question of whether their presence reflects an expression of transformation or whether normal monocytes undergo a developmental stage in which...

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Bibliografiska uppgifter
I publikationen:J Clin Invest
Huvudupphovsmän: Welgus, H G, Connolly, N L, Senior, R M
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 1986
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC424573/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3009552/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112485
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