High-Performing Dry Powder Inhalers of Paclitaxel DPPC/DPPG Lung Surfactant-Mimic Multifunctional Particles in Lung Cancer: Physicochemical Characterization, In Vitro Aerosol Dispersion, and Cellular Studies

Inhalable lung surfactant-based carriers composed of synthetic phospholipids, dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylglycerol (DPPG), along with paclitaxel (PTX), were designed and optimized as respirable dry powders using organic solution co-spray-drying particle engineeri...

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Bibliographic Details
Published in:AAPS PharmSciTech
Main Authors: Meenach, Samantha A., Anderson, Kimberly W., Hilt, J. Zach, McGarry, Ronald C., Mansour, Heidi M.
Format: Artigo
Language:Inglês
Published: Springer US 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245438/
https://ncbi.nlm.nih.gov/pubmed/25139763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-014-0182-z
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