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Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.

To determine the biochemical basis of the oxidant-induced injury of cells, we have studied early changes after exposure of P388D1 murine macrophages to hydrogen peroxide. Total intracellular NAD+ levels in P388D1 cells decreased with H2O2 concentrations of 40 microM or higher. Doses of H2O2 between...

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Published in:J Clin Invest
Main Authors: Schraufstatter, I U, Hinshaw, D B, Hyslop, P A, Spragg, R G, Cochrane, C G
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1986
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC424485/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2937805/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112436
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