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A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks
Functional interpretation of genomic variation is critical to understanding human disease but it remains difficult to predict the effects of specific mutations on protein interaction networks and the phenotypes they regulate. We describe an analytical framework based on multiscale statistical mechan...
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| Publié dans: | Nat Genet |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4244270/ https://ncbi.nlm.nih.gov/pubmed/25362484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3138 |
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