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The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity

S-acylation, the attachment of fatty acids onto cysteine residues, regulates protein trafficking and function and is mediated by a family of zDHHC enzymes. The S-acylation of peripheral membrane proteins has been proposed to occur at the Golgi, catalyzed by an S-acylation machinery that displays lit...

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Vydáno v:Mol Biol Cell
Hlavní autoři: Lemonidis, Kimon, Gorleku, Oforiwa A., Sanchez-Perez, Maria C., Grefen, Christopher, Chamberlain, Luke H.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Cell Biology 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4244197/
https://ncbi.nlm.nih.gov/pubmed/25253725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-06-1169
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