The pharmacokinetics and pharmacodynamics of denosumab in patients with advanced solid tumours and bone metastases: a systematic review

AIM: The objective of this systematic review was to characterize the pharmacokinetics and pharmacodynamics of denosumab (XGEVA®), a fully human IgG2 monoclonal antibody which binds to receptor activator of nuclear factor kappa-B ligand (RANKL), for the treatment of skeletal-related events (SREs) in...

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Bibliographische Detailangaben
Veröffentlicht in:Br J Clin Pharmacol
Hauptverfasser: Sohn, Winnie, Simiens, Mary Ann, Jaeger, Kelly, Hutton, Shauna, Jang, Graham
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2014
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Reviews
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243899/
https://ncbi.nlm.nih.gov/pubmed/24548274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12355
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