Interaction of clopidogrel and statins in secondary prevention after cerebral ischaemia – a randomized, double-blind, double-dummy crossover study

AIMS: Variability in responsiveness to clopidogrel is a clinical problem in secondary prevention after cerebral ischaemia which has been suggested to be linked to competitive metabolization of clopidogrel and cytochrome P450 (CYP) 3A4-oxidated statins such as simvastatin. We assessed the hypothesis...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Siepmann, Timo, Heinke, Denise, Kepplinger, Jessica, Barlinn, Kristian, Gehrisch, Siegmund, Grählert, Xina, Schwanebeck, Uta, Reichmann, Heinz, Puetz, Volker, Bodechtel, Ulf, Gahn, Georg
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Drug Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243880/
https://ncbi.nlm.nih.gov/pubmed/24803100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12416
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