Bilastine vs. hydroxyzine: occupation of brain histamine H(1)-receptors evaluated by positron emission tomography in healthy volunteers

AIM: A close correlation exists between positron emission tomography (PET)-determined histamine H(1)-receptor occupancy (H(1)RO) and the incidence of sedation. Antihistamines with H(1)RO <20% are classified as non-sedating. The objective was to compare the H(1)RO of bilastine, a second generation...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Farré, Magí, Pérez-Mañá, Clara, Papaseit, Esther, Menoyo, Esther, Pérez, Marta, Martin, Soraya, Bullich, Santiago, Rojas, Santiago, Herance, José-Raúl, Trampal, Carlos, Labeaga, Luis, Valiente, Román
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Pharmacodynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243871/
https://ncbi.nlm.nih.gov/pubmed/24833043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12421
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