The role of maternal-specific H3K9me3 modification in establishing imprinted X-chromosome inactivation and embryogenesis in mice

Maintaining a single active X-chromosome by repressing Xist is crucial for embryonic development in mice. Although the Xist activator RNF12/RLIM is present as a maternal factor, maternal Xist (Xm-Xist) is repressed during preimplantation phases to establish imprinted X-chromosome inactivation (XCI)....

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Fukuda, Atsushi, Tomikawa, Junko, Miura, Takumi, Hata, Kenichiro, Nakabayashi, Kazuhiko, Eggan, Kevin, Akutsu, Hidenori, Umezawa, Akihiro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Pub. Group 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243243/
https://ncbi.nlm.nih.gov/pubmed/25394724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6464
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