Attrition of T-Cell Functions and Simultaneous Upregulation of Inhibitory Markers Correspond with the Waning of BCG-Induced Protection against Tuberculosis in Mice

Mycobacterium bovis bacille Calmette-Guérin (BCG) is the most widely used live attenuated vaccine. However, the correlates of protection and waning of its immunity against tuberculosis is poorly understood. In this study, we correlated the longitudinal changes in the magnitude and functional quality...

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Publicado en:PLoS One
Autores principales: Nandakumar, Subhadra, Kannanganat, Sunil, Posey, James E., Amara, Rama Rao, Sable, Suraj B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4242676/
https://ncbi.nlm.nih.gov/pubmed/25419982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0113951
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