Defective binding and function of 1,25-dihydroxyvitamin D3 receptors in peripheral mononuclear cells of patients with end-organ resistance to 1,25-dihydroxyvitamin D.

Lectin-induced DNA synthesis by peripheral mononuclear cells from 17 normal donors was inhibited (40-60%) by 1,25-dihydroxyvitamin D3 (1,25[OH]2D3) at physiological concentrations (10(-10)-10(-9) M). The lymphocytes acquire specific receptors for 1,25(OH)2D3 upon activation by the lectins. This proc...

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Autori principali: Koren, R, Ravid, A, Liberman, U A, Hochberg, Z, Weisman, Y, Novogrodsky, A
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1985
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC424267/
https://ncbi.nlm.nih.gov/pubmed/2997300
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