Pathophysiology and pathogenesis of stunned myocardium. Depressed Ca2+ activation of contraction as a consequence of reperfusion-induced cellular calcium overload in ferret hearts.

Contractile dysfunction in stunned myocardium could result from a decrease in the intracellular free [Ca2+] transient during each beat, a decrease in maximal Ca2+-activated force, or a shift in myofilament Ca2+ sensitivity. We measured developed pressure (DP) at several [Ca]0 (0.5-7.5 mM) in isovolu...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Autores principales: Kusuoka, H, Porterfield, J K, Weisman, H F, Weisfeldt, M L, Marban, E
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 1987
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC424246/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3818956/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112906
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