Pathophysiology and pathogenesis of stunned myocardium. Depressed Ca2+ activation of contraction as a consequence of reperfusion-induced cellular calcium overload in ferret hearts.

Contractile dysfunction in stunned myocardium could result from a decrease in the intracellular free [Ca2+] transient during each beat, a decrease in maximal Ca2+-activated force, or a shift in myofilament Ca2+ sensitivity. We measured developed pressure (DP) at several [Ca]0 (0.5-7.5 mM) in isovolu...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Kusuoka, H, Porterfield, J K, Weisman, H F, Weisfeldt, M L, Marban, E
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1987
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC424246/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3818956/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112906
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