An optimized nanoparticle delivery system based on chitosan and chondroitin sulfate molecules reduces the toxicity of amphotericin B and is effective in treating tegumentary leishmaniasis

Amphotericin B (AmpB) is active against leishmaniasis, but its use is hampered due to its high toxicity observed in patients. In this study, a nanoparticles-delivery system for AmpB (NQC-AmpB), containing chitosan and chondroitin sulfate molecules, was evaluated in BALB/c mice against Leishmania ama...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Ribeiro, Tatiana G, Franca, Juçara R, Fuscaldi, Leonardo L, Santos, Mara L, Duarte, Mariana C, Lage, Paula S, Martins, Vivian T, Costa, Lourena E, Fernandes, Simone OA, Cardoso, Valbert N, Castilho, Rachel O, Soto, Manuel, Tavares, Carlos AP, Faraco, André AG, Coelho, Eduardo AF, Chávez-Fumagalli, Miguel A
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4242406/
https://ncbi.nlm.nih.gov/pubmed/25429219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S68966
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